E-cigarette nicotine
In the wave of tobacco product iterations, e-cigarettes (also known as "atomized cigarettes" or "nicotine mouth pouches"), as a new type of smokeless gas product, are rapidly changing the global consumption pattern. Unlike traditional tobacco, which relies on combustion to release nicotine, e-cigarettes use food-grade excipients with slow-release technology to gradually release nicotine in the mouth: not only meeting the needs of users, but also avoiding the harm of second-hand smoke and environmental pollution. Along with the growth of the industry, the quality uniformity and release stability of each brand has become the focus of regulatory and consumer attention. As the core component of e-cigarettes, the release behavior of nicotine directly determines the effectiveness and safety of the product. If the release is too fast, it may cause side effects such as nausea and dizziness; if the release is too slow, it will lead to a lack of satisfaction and affect the user experience.
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Experimental parameters
| Main analytical instruments | RT700 |
| Elution device | Large Cell (22.6mm) |
| Flow velocity | 8 mL/min |
| Operating mode | open loop |
| Pulsation mode | 0Hz |
| Temperature | 37.0 ± 0.5 ℃ |
| Dissolution medium | pH6.8 phosphate buffer |
Experimental result
Considering the release environment of e-cigarettes in the oral cavity (flat salivary secretion) we used flow-through cell method in order to perform dynamic oral environment simulation.
In flow-through cell method test: Raytor RT700 flow cell method supports intensive sampling in seconds (accurately capturing the phenomenon of rapid release), we were able to obtain the nicotine release data of the e-cigarette before 2min, and the dissolution data suggests that the nicotine release is a little slower in the gentle shear environment of flow-through cell method (the average release amount of 31.09% in 15min), with a relative standard deviation of 3.61% - 6.34%.
Summarizing: A new use of dissolution technology
--The leap from pharmaceuticals to e-cigarettes
The explosive growth of new products such as e-cigarettes and oral nicotine pouches has pushed their quality control systems towards refinement and standardization. This case study shows that the application value of dissolution instrument is not only limited to the pharmaceutical field, but also brings a new application direction for other industries such as electronic cigarettes. As an innovator of dissolution technology, Raytor Instruments will provide you with dissolution test equipment and solutions covering the whole scenario with high precision and strict requirements!
