Activated Oxygen Sensitive Hydrogel
A double selenium bond-bridged burdock sapogenin (ATG)-chitosan (CS) copolymer and further made into a ROS-sensitive hydrogel (ATG-CS-Gel).
Get Free Quote
Experimental parameters
| Dissolution apparatus | RT6 Series Automated Dissolution System |
| Method | A dissolution cup containing 200 mL of PBS (pH 7.4, 2% SDS) with or without (0.4% H₂O₂) |
Experimental results
ATG-CSATG-CS (11 % modification) was selected as the optimal prescription because of the breakage of the diselenide bond in 0.4 % H2O2 solution, the fastest ROS-responsive drug release within 1 h (81.6 % in 4 h), and the highest water solubility and swelling rate.
In subsequent pharmacodynamic evaluations, the prescription demonstrated excellent therapeutic effects in both Caco-2 cells and a mouse model of colitis: e.g., adherence to the colonic lesion for up to 24 hours; superiority over the control drug mesalazine in improving the activity index, colon length, and intestinal tissue damage in mice; and a high potential for repairing the intestinal mucosal barrier by modulation of MLCK, among others. These results indicate that the results of in vitro drug release, water solubility, and dissolution rate tests do provide strong support for subsequent biologically relevant tests.
CONCLUSION: Raytor RT6 Series Automated Dissolution System, on the other hand, accurately predicts the optimal prescription, improves experimental efficiency and reduces the number of experimental animals.
RT614-ST Automated Dissolution System
- Accurate Sampling
- Pipeline System
- Automatic Online Filtering
- Automatic Sample Collection
Learn More
RT612-ST Automated Dissolution System
- High-pressure Resistant Pipeline
- Anti-corrosive Injection Needles
- Flexible Sampling Parameterization
- Optional Dual Drive
Learn More
RT600 Dissolution Apparatus
- Covered Dissolving Cups
- Convenient Sampling
- Automatic Synchronous Dosing
- Infinite Data Storage
Learn More
RT600-ST Automated Dissolution System
- High Anti-adsorption Pipeline
- High-precision Sampling
- Complete Filtration Solutions
- Optional Online Dilution
Learn More
RT612 Dissolution Apparatus
- Individual Temperature Monitoring
- Real-time Monitoring of Vital Parameters
- Intelligent Dosing Device
- Optional Dual Drive
Learn More
RT600-UV Online UV Dissolution System
- Various pathlengths Support:Supports various flow cells with pathlengths from 1 to 10 mm
- Prevent cross-contamination:Individual flow cells and lines for each dissolution vessel prevent cross-contamination
- Dissolution analysis software: UV dissolution analysis software uses a multi-cell platform to generate accurate and stable data for various samples and methods
- Regulatory complexity: Software supports all regulatory requirements of 21 CFR Part 11
Learn More