Ciprofloxacin
Ciprofloxacin is a fluoroquinolone antibiotic used to treat a number of bacterial infections. This includes bone and joint infections, intra-abdominal infections, certain types of infectious diarrhea, respiratory tract infections, skin infections, typhoid fever, and urinary tract infections, among others. For some infections it is used in addition to other antibiotics. It can be taken by mouth, as eye drops, as ear drops, or intravenously.
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Experimental parameters
| Experimental conditions | Controlexperiment | Samples 1 | Samples 2 |
| Bionic Membrane | Raytor Bio-Flux Membrane | Raytor Bio-Flux Membrane | Raytor Bio-Flux Membrane |
| Supply side | pH 6.5 buffer | pH 6.5 buffer（20% ethanol） | pH 6.5 buffer（20% ethanol） |
| Receiving side | pH 7.4 buffer | pH 7.4 buffer | pH 7.4 buffer |
| API | Ciprofloxacin, which was added immediately after the start of the experiment | Ciprofloxacin, which was added immediately after the start of the experiment | Ciprofloxacin, which was added immediately after the start of the experiment |
Experimental result
The blood concentration of a drug in the body depends on its in vivo dissolution and small intestinal osmotic absorption, in the case study API ciprofloxacin is an amphoteric BCS3 analog, which is fairly well solubilized in small intestinal conditions in the human body. This sharing utilizes the presence or absence of alcohol in the dissolution medium to investigate how alcohol will affect the absorption of ciprofloxacin.
Permeability studies of ciprofloxacin (PAMPA method) were carried out using the simulated physiological conditions in the Raytor NCE DP. Since ciprofloxacin is a BCS3 drug, the solvents were used only in the level 0 physiological simulation and the experimental conditions were as follows:
Conclusion:
The results of the PAMPA experiment in NCE DP show that the permeability of impermeable drugs seems to increase when alcohol is present in the small intestine, which is consistent with our experience of "take drugs not alcohol, drink alcohol not drugs", although increased absorption of the drug can provide better efficacy, excessive absorption of the drug can pose serious health risks to the user. This is consistent with our experience of "take drugs, not alcohol".
